Influence of silica nanoparticles on phase behavior and structural properties of DPPC-Palmitic acid Langmuir monolayers

► We studied lipid monolayers spread on water and silica nanoparticle dispersions. ► The surface pressure response to area compression-expansion is modified. ► Partially hydrophobic nanoparticle-lipid complexes are incorporated in the layer. ► Nanoparticles hinder the lipids ordering and the condensed phase formation ► Different monolayer phase behavior and morphology are observed with particles.