کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
69916 | 48800 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biocatalyzed kinetic resolution of racemic mixtures of chiral α-aminophosphonic acids Biocatalyzed kinetic resolution of racemic mixtures of chiral α-aminophosphonic acids](/preview/png/69916.png)
Several fungal species namely: Aspergillus niger, Aspergillus parasiticus, Penicillium funiculosum, Trigonopsis variabilis and two different strains of Fusarium oxysporum were tested toward racemic mixtures of following phosphonic acids: 1-amino-2-methylpropanephosphonic acid, 1-aminophenylmethanephosphonic acid and 1-amino-2-phenylethanephosphonic acid. Application of F. oxysporum strain (UW1) allowed obtaining optically pure S-isomer of 1-aminophenylmethanephosphonic acid and R-isomer of 1-amino-2-phenylethanephosphonic acid, whereas biotransformation of racemic mixture of 1-amino-2-methylpropanephosphonic acid with F. oxysporum strain (DSM 12646) cells resulted in obtaining pure enantiomer of R-configuration.
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► Fungal cells were applied to resolve racemic mixtures of α-aminophosphonic acids.
► This microbial transformation is considered as kinetically controlled bioconversion.
► The most potent appeared to be two different strains of Fusarium oxysporum.
► Optically pure enantiomers of ValP, PheP and PhgP were obtained.
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 91, July 2013, Pages 32–36