کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70156 48813 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trypsin-catalyzed direct asymmetric aldol reaction
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Trypsin-catalyzed direct asymmetric aldol reaction
چکیده انگلیسی

Unnatural catalytic activity of trypsin from porcine pancreas for direct asymmetric aldol reaction was discovered. The reactions between aromatic aldehydes and various ketones gave products in moderate yields and enantioselectivities in the presence of a small amount of water. The influences of solvent, water content, temperature, mole ratio of substrates, and enzyme concentration were investigated. The mechanism of trypsin-catalyzed aldol reaction was discussed. This enzymatic promiscuity widens the application of trypsin to new chemical transformations.

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► Unnatural catalytic activity of trypsin from porcine pancreas for direct asymmetric aldol reaction was discovered.
► Mechanism of trypsin-catalyzed aldol reaction was hypothesized.
► This enzymatic promiscuity widens the application of trypsin to new chemical transformations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 87, March 2013, Pages 83–87
نویسندگان
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