کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70276 48820 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Utilization of biocatalytic promiscuity for direct Mannich reaction
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Utilization of biocatalytic promiscuity for direct Mannich reaction
چکیده انگلیسی

A lipase-catalyzed direct Mannich reaction of arylamines with aromatic aldehydes and ketones including cyclohexanone, butanone and 1-hydroxy-2-propanone was developed under EtOH/H2O system in a “one-pot” strategy. A series of experiments on the promiscuous activity of lipases were performed to optimize the biocatalytic process, and a wide scope of substrates was expanded with good yields.

A lipase-catalyzed direct Mannich reaction of arylamines with aromatic aldehydes and ketones was developed under EtOH/H2O system in a “one-pot” strategy. A series of experiments on the promiscuous activity of lipases were performed to optimize the biocatalytic process, and a wide scope of substrates was expanded..Figure optionsDownload as PowerPoint slideResearch highlights▶ The Mannich reaction was realized in “one pot” strategy in the presence of water. ▶ Solvents play an impartment role in this lipase promiscuious catalyzed Mannich reaction and protic solvents are better for this reaction. ▶ Water content has a great effect on the enzyme activity. ▶ The reaction was favored by electron-withdrawing substituents of aldehyde.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 67, Issues 3–4, December 2010, Pages 189–194
نویسندگان
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