Optimization of dilute acid-based pretreatment and application of laccase on apple pomace

► Apple pomace is a polysaccharide-rich under-utilized substrate for bio-processes. ► Optimization of the key pretreatment conditions using surface response methodology. ► Laccase treatment degraded 85% of inhibitory phenolic compounds of the hydrolyzate. ► The mild acid pretreatment produced low amounts of inhibitory furans and acetate. ► Enhancements of digestibility of apple lignocellulose allow efficient bioconversion.