Lipase-mediated preparation of optically active isomers of Rosaphen®

The optically active isomers of Rosaphen® (RS)-1 were synthesized from the chiral intermediate prepared by lipase-catalyzed desymmetrization of prochiral diol. The results of an olfactory evaluation of the prepared isomers are reported.

Figure optionsDownload as PowerPoint slideResearch highlights▶ A chiral primary alcohol was prepared by lipase-catalyzed reaction. ▶ The primary alcohol was converted to the enantiomers of Rosaphen®. ▶ An olfactory evaluation of the isomers was performed.