Lipase-catalysed resolution of N-(3-cyano-2-hydroxy propan-1-yl)phthalimide: Synthesis of (R)-GABOB and (R)-carnitine

The lipase-mediated resolution of N-(3-cyano-2-hydroxy propan-1-yl)phthalimide using various lipases in different solvents has been studied and this intermediate was utilized towards the synthesis of enantiomerically enriched (R)-GABOB and (R)-carnitine in high yields.

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