کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
71187 | 48882 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of optically pure halogenated phenyl 2-hydroxypropanones by lipase-catalyzed enantioselective transesterification
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of optically pure halogenated phenyl 2-hydroxypropanones by lipase-catalyzed enantioselective transesterification Synthesis of optically pure halogenated phenyl 2-hydroxypropanones by lipase-catalyzed enantioselective transesterification](/preview/png/71187.png)
چکیده انگلیسی
Lipase-catalyzed enantioselective transesterification has been performed to obtain chiral halogenated phenyl 2-hydroxypropanones, key intermediates of pharmaceuticals. Effects of organic solvents, reaction temperature, and substrate concentration were also investigated in Novozym 435-catalyzed transesterification of 1-(2,4-difluorophenyl)-2-hydroxypropanone with vinyl butanoate. Optically pure halogenated phenyl 2-hydroxypropanones and their esters have been successfully prepared in good yields (>40%) and excellent enantiopurities (>99%) by Novozym 435-catalyzed transesterification at 30 °C in hexane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 48, Issues 1–2, 3 September 2007, Pages 38–41
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 48, Issues 1–2, 3 September 2007, Pages 38–41
نویسندگان
Nan Young Jeon, Sung-Jin Ko, Yeon Soo Lee, Bum Tae Kim, Keehoon Won, Hyuk Lee,