Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta

The microbial transformation of 10-deacetylbaccatin III (10-DAB) (1a) and 13-DeBAC (4b) was investigated. Trametes hirsuta induced 13-oxidation of 10-DAB to give (4a) in high yield, whereas incubation with Curvularia lunata resulted in the isolation of the 7-epi-10-DAB (2) and the 7-epi-10-oxo-10-DAB (3). 13-DeBAC (4b) was biotransformed into compounds (4a) and (4c) by Alternaria alternata.