کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
71215 | 48888 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Lactones 27 [1]: Transformations of γ-lactones fused to a dimethylcyclohexane ring in Absidia cylindrospora cultures Lactones 27 [1]: Transformations of γ-lactones fused to a dimethylcyclohexane ring in Absidia cylindrospora cultures](/preview/png/71215.png)
Two saturated (4a,b) and one unsaturated (5) bicyclic γ-lactones containing a dimethylcyclohexane ring were subjected to biotransformation using the fungal strain Absidia cylindrospora. Six new compounds (6–11) and one known (12) [K.W. Rosenmund, H. Herzberg, H. Schutt, Chem. Ber. 87 (1954) 1258] [2] were isolated. All substrates were stereoselectively hydroxylated by the microorganism at either the C-4 (in the case of 4a and 5) or C-2 position (in case of 4a and 4b) giving the corresponding hydroxylactones with tertiary (6 and 9) or secondary (8 and 10) hydroxy groups, respectively.The hydroxy group was also introduced into C-3 (in the case of 4a) and C-6 (in the case of 4b) positions. The structures of all obtained products were established on the basis of their spectral data. In the case of lactones 8–10 these structures were undoubtedly confirmed by their X-ray analysis.
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 39, Issues 1–4, 2 May 2006, Pages 31–39