کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7266287 | 1472913 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spatial and temporal summation of pain evoked by mechanical pressure stimulation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Chronic pain patients often suffer from widespread and long lasting pain. The integrative effect of combined spatial and temporal summation on pain intensity has not been quantitatively tested. The present study was designed to investigate: (1) if the size of the stimulation area would facilitate the temporal summation of pain to repetitive pressure stimulation, and (2) if temporal summation is effective when stimulating separated sites, repetitively. Twenty healthy male subjects participated in this study. The test sites were located on the bilateral upper trapezius and tibialis anterior muscles. The ten stimuli (each with a duration of 1Â s) were applied to a single site at three inter-stimulus intervals (ISI: 1, 5, 30Â s) using five different probe sizes (0.5, 1, 2, 4 and 8Â cm2). The stimulation intensity was equal to the pressure pain threshold (PPT) determined for each probe size. Similar repetitive stimulations at two inter-stimulus intervals (5Â s and 30Â s) using two sizes of probes (0.5Â cm2 and 2Â cm2) were applied to ten separate sites. The PPT at the trapezius muscle decreased significantly with the increase in stimulus area from 0.5Â cm2 to 8Â cm2 (PÂ <Â 0.001) due to spatial summation. Temporal summation of pain was evoked by repetitive pressure stimuli on the same site for all ISI and was more pronounced at 5Â s and 30Â s ISI with larger probe areas (2, 4, and 8Â cm2) compared to smaller probe areas. There was no temporal summation of pain to stimuli with ISI 5 and 30Â s when stimulating the separated sites. The current study indicated that spatial summation facilitated the temporal summation of pain for stimuli given at 5Â s and 30Â s ISI. The combination of temporal and spatial integration of nociceptive input facilitates the pain intensity, suggesting that temporal summation is clinically relevant in conditions with widespread pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pain - Volume 13, Issue 6, July 2009, Pages 592-599
Journal: European Journal of Pain - Volume 13, Issue 6, July 2009, Pages 592-599
نویسندگان
HongLing Nie, Thomas Graven-Nielsen, Lars Arendt-Nielsen,