Ionic liquid-based ordered mesoporous organosilica-supported copper as a novel and efficient nanocatalyst for the one-pot synthesis of Biginelli products

• A copper containing ionic liquid based nanomaterial was prepared and characterized.
• This material was applied as an efficient nanocatalyst for the Biginelli reaction.
• The Biginelli products were obtained in high to excellent yields and selectivities.
• The catalyst was reused several times without important decrease in efficiency.
• Excellent properties of the catalyst have also been developed in details.

The preparation, characterization and catalytic application of a novel copper-loaded ionic liquid-based periodic mesoporous organosilica (Cu@PMO-IL) are described. The mesoporous structure of the Cu@PMO-IL material is characterized by transmission electron microscopy (TEM) and nitrogen adsorption–desorption analysis. The thermal stability of the material is also determined by thermal gravimetric analysis (TGA). The presence of copper species in the material framework is confirmed by X-ray photoelectron spectroscopy (XPS) and elemental analysis (EA). The catalytic application of Cu@PMO-IL nanocatalyst is then investigated in the Biginelli condensation of different aldehydes with urea and alkylacetoacetates under solvent-free conditions and at moderate temperature. Moreover, the stability, reactivity and reusability of the catalyst are improved under applied reaction conditions.

A novel copper containing ionic liquid based periodic mesoporous organosilica was prepared, characterized and its catalytic activity was investigated in the synthesis of 3,4 dihydropyrimidinones via Biginelli reaction. This catalyst exhibited high efficiency for the preparation of different derivatives of Biginelli products under moderate reaction conditions. Moreover, the catalyst was successfully recovered and reused many times without important decrease in reactivity and selectivity.Figure optionsDownload as PowerPoint slide