کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7280462 | 1473913 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis](/preview/png/7280462.png)
چکیده انگلیسی
Elevated CXCL13 within the central nervous system (CNS) correlates with humoral responses in several neuroinflammatory diseases, yet its role is controversial. During coronavirus encephalomyelitis CXCL13 deficiency impaired CNS accumulation of memory B cells and antibody-secreting cells (ASC) but not naïve/early-activated B cells. However, despite diminished germinal center B cells and follicular helper T cells in draining lymph nodes, ASC in bone marrow and antiviral serum antibody were intact in the absence of CXCL13. The data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 54, May 2016, Pages 128-139
Journal: Brain, Behavior, and Immunity - Volume 54, May 2016, Pages 128-139
نویسندگان
Timothy W. Phares, Krista D. DiSano, Stephen A. Stohlman, Benjamin M. Segal, Cornelia C. Bergmann,