کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7281388 1473922 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal dysfunctions caused by cranial irradiation: A review of the experimental evidence
ترجمه فارسی عنوان
اختلالات هیپوکامپ ناشی از تابش جمجمه: بررسی شواهد تجربی
کلمات کلیدی
تابش جراحی، اختلال هیپوکامپ، نوروژنز، نوروتروفین، عصب خونی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Cranial irradiation (IR) is commonly used for the treatment of brain tumors but may cause disastrous brain injury, especially in the hippocampus, which has important cognition and emotional regulation functions. Several preclinical studies have investigated the mechanisms associated with cranial IR-induced hippocampal dysfunction such as memory defects and depression-like behavior. However, current research on hippocampal dysfunction and its associated mechanisms, with the ultimate goal of overcoming the side effects of cranial radiation therapy in the hippocampus, is still very much in progress. This article reviews several in vivo studies on the possible mechanisms of radiation-induced hippocampal dysfunction, which may be associated with hippocampal neurogenesis, neurotrophin and neuroinflammation. Thus, this review may be helpful to gain new mechanistic insights into hippocampal dysfunction following cranial IR and provide effective strategies for potential therapeutic approaches for cancer patients receiving radiation therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 45, March 2015, Pages 287-296
نویسندگان
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