کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7298829 | 1475124 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GABA function may be related to the impairment of learning and memory caused by systemic prenatal hypoxia-ischemia
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کلمات کلیدی
EAATNMDAN-methyl-d-aspartic acidNADPH-diaphoraseMAO-BPFAGADHRPTBSHIENADPH-dIPSCPBSBSA - BSAglutamic acid decarboxylase - glutamic acid dearboxylasebovine serum albumin - آلبومین سرم گاوHypoxic-ischemic encephalopathy - آنسفالوپاتی ناشی از هیپوکسی-ایسکمیکγ-aminobutyric acid - اسید γ-آمینوبوتیریکphosphate buffer - بافر فسفاتTris-buffered saline - تریس بافر شورnovel object recognition test - تست تشخیص جدید رمانinhibitory postsynaptic current - جریان پستانیپتیک مهارکنندهexcitatory amino acid transporter - حمل کننده آمینو اسید هیجان انگیزPCs - رایانه های شخصیDevelopment - رشدPrincipal cells - سلولهای اصلیAmmon’s horn - شاخ آمونdentate gyrus - شکنج دندانه دارPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRats - موش صحراییmonoamine oxidase-B - مونوآمین اکسیداز-BNORT - نورتHippocampus - هیپوکامپ hypoxia-ischemia - هیپوکسی-ایسکمیparaformaldehyde - پارافرمالدهیدHorseradish peroxidase - پراکسیداز هوررادیشGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant rat is obstructed for 45â¯min we have described oligodendrocyte death, astrogliosis and neuronal loss. In this work we investigated hippocampal neuronal population and performed a functional evaluation of memory and learning of young rats that had been affected by prenatal HI. Anesthetized Wistar rats on the 18th gestation day had the uterine horns exposed and the ovarian and uterine arteries clamped for 45â¯min (HI group). Sham-operated rats (SH group) had the horns exposed but no arteries were clamped. We measured the levels of different proteins related to excitatory/inhibitory transmission in the hippocampi of young pups (P45). Histological evaluation was also performed in order to characterize hippocampal neuronal population. Rats from both groups were tested through Novel Object Recognition Test (NORT) using two inter-trial intervals: 5â¯min and 8â¯h. Here we show a loss in the total number of hippocampal neurons although the immunostaining of parvalbumin and levels of GAD enzyme were increased in HI group. Functional assessment indicated a marked difference concerning HI learning and memory abilities. Our results reflect permanent damages concerning GABA function which may disturb neurotransmitter homeostasis leading to the observed deficits in learning and memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 149, March 2018, Pages 20-27
Journal: Neurobiology of Learning and Memory - Volume 149, March 2018, Pages 20-27
نویسندگان
Marta Cristina Cunha-Rodrigues, Cassiana Thayara do Nascimento Balduci, Frank Tenório, Penha Cristina Barradas,