کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
73498 49062 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mesoporous silica based macromolecules for dissolution enhancement of Irbesartan drug using pre-adjusted pH method
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Mesoporous silica based macromolecules for dissolution enhancement of Irbesartan drug using pre-adjusted pH method
چکیده انگلیسی

Dissolution enhancement of poorly water-soluble Irbesartan drug through formation of Irbesartan-silica based microcapsules has been investigated. The microcapsules were fully characterized using FTIR, DSC, XRD and SEM techniques. Pre-adjusted pH method has been utilized to form efficient Irbesartan–silica based microcapsules capable to enhance dissolution rate of Irbesartan drug at the challenging pH 5.5 value. The formed Irbesartan–silica based microcapsules showed large dissolution increase as Neusilin feed ratio and as pre-adjusted pH were increased. The maximum dissolution enhancement was achieved via salt formation at pre-adjusted pH 7.4 and 1:3 ratio of Irbesartan-silica based microcapsules. The successful dissolution enhancement was owed to destruction of the crystallinity of the drug accompanied with Irbesartan-silica based salt formation at elevated pH pre-adjustment leading to apparent drug dissolution.

Figure optionsDownload as PowerPoint slideHighlights
► Dissolution enhancement of poorly water-soluble Irbesartan via silica microcapsules investigated.
► The microparticles were fully characterized using FTIR, DSC, XRD and SEM techniques.
► Pre-adjusted pH method was established to enhance dissolution at challenging pH 5.5.
► The maximum dissolution using microcapsules and pre-adjusted pH method at pH 7.4 was 92.5%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 173, June 2013, Pages 22–28
نویسندگان
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