کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
73751 | 49070 | 2013 | 6 صفحه PDF | دانلود رایگان |

Zeolite Y with different silica to alumina ratios varying from 5 to 60 was used as a host for the chemotherapy drug, 5-fluorouracil. The 5-fluorouracil content in the zeolites was approximately 90–110 mg/g as determined by thermogravimetric analysis. Nitrogen adsorption–desorption measurements were used to measure the surface area and the pore volume of the zeolites before and after 5-fluorouracil loading. The decrease in surface areas and pore volumes after drug loading was attributed to the inclusion of 5-fluorouracil in the zeolite pores. FTIR spectroscopy provided evidence of molecular level interactions of the 5-fluorouracil with the zeolite. 27Al NMR indicated that the 5-fluorouracil interacted with the zeolite through the extraframework aluminum sites. Release profiles under physiological conditions were also conducted and indicated that the aluminum content was critical in determining the extent of release of 5-fluorouracil. HY-5 with the lowest SiO2/Al2O3 released less than 5% of the loaded 5-fluorouracil while HY-30 and HY-60 released approximately 56% and 63% of the loaded 5-FU, respectively.
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► 5-Fluorouracil (5-FU), a chemotherapy drug, was loaded into HY zeolites.
► The effect of the silica to alumina ratio on loading and release was investigated.
► The highest aluminum content in HY resulted in the lowest 5-fluorouracil release.
► FTIR and 27Al NMR were used to provide molecular level insights.
► The low release was attributed to the formation of a strongly bound 5-FU/aluminum complex as supported by the 27Al NMR.
Journal: Microporous and Mesoporous Materials - Volume 167, February 2013, Pages 182–187