Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection

► Sensitive and precise HPLC method with electrochemical detection. ► Simultaneous determination of four alkaloids in Rhizoma Coptidis by LC-ECD. ► Highly sensitive analysis of jatrorrhizine, coptisine, palmatine and berberine in rat plasma after oral administration. ► Elimination of interference from endogenous components.