کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7609288 | 1493395 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A review on chiral separation by counter-current chromatography: Development, applications and future outlook
ترجمه فارسی عنوان
بررسی در مورد جداسازی کروی با استفاده از کروماتوگرافی ضد جریان: توسعه، برنامه های کاربردی و چشم انداز آینده
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کلمات کلیدی
CPCHSCCCCCCBCRREMCLRMDMHPCCCChiral separation - جدایی کریالStationary phase - فاز ثابتMobile phase - فاز موبایلHigh-speed counter-current chromatography - کروماتوگرافی با سرعت بالا ضد جریانCounter-current chromatography - کروماتوگرافی جریان مخالفHigh-performance counter-current chromatography - کروماتوگرافی ضد جریان با عملکرد بالاhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراCentrifugal partition chromatography - کروماتوگرافی پارتیشن گریز از مرکز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Chiral separation has been a remarkably active area of research over the past long time and it still stays that way. Over the last few decades, counter-current chromatography (CCC) was successfully applied to the field of chiral separation. It provides an attractive approach to obtain pure enantiomer, particularly in preparative application because of its unique advantages of high load capacity, low solvent consumption and easy scale-up. The last several years great strides have been made in chiral separation by CCC, ranging from novel elution modes such as recycling elution mode and multiple dual mode elution to more specialized approaches such as pH-zone-refining and biphasic chiral recognition technologies. These developments have greatly improved the resolution of enantiomers and promoted the application of CCC in the field of chiral separation. Although not as popular as its application to the field of separation of natural product, the development of chiral separation by CCC should not be underrated. In this review article, we refer to the development, applications and future outlook of chiral separation by CCC, with emphasis on topics of its history, mechanism, advantages, limitations, current development and challenges. Meanwhile, its orientation of continued evolution and future outlook also have been discussed. While some scientific and technological problems have not yet been solved thoroughly, chiral separation by CCC has demonstrated potential advantages and prospects in this field and has good chance at preparative enantioseparation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1531, 5 January 2018, Pages 1-12
Journal: Journal of Chromatography A - Volume 1531, 5 January 2018, Pages 1-12
نویسندگان
Xin-Yi Huang, Dong Pei, Jian-Fei Liu, Duo-Long Di,