کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7610368 1493495 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leveraging probabilistic peak detection to estimate baseline drift in complex chromatographic samples
ترجمه فارسی عنوان
کشف پیک احتمالی برای تخمین ریزش پایه در نمونه های کروماتوگرافی پیچیده
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
We present a baseline estimation method that leverages a probabilistic peak detection algorithm. A posterior probability of being affected by a peak is computed for each point in the chromatogram, leading to a set of weights that allow non-iterative calculation of a baseline estimate. For extremely saturated chromatograms, the peak weighted (PW) method demonstrates notable improvement compared to the other methods examined. However, in chromatograms characterized by low-noise and well-resolved peaks, the asymmetric least squares (ALS) and the more sophisticated Mixture Model (MM) approaches achieve superior results in significantly less time. We evaluate the performance of these three baseline correction methods over a range of chromatographic conditions to demonstrate the cases in which each method is most appropriate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1431, 29 January 2016, Pages 122-130
نویسندگان
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