کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7613534 1493589 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry
ترجمه فارسی عنوان
رین کارباموییل نوع کینین و مبدل های آنیونی کرییدی بر پایه کوینیدین، اجرای شیمیایی بی حرکت سازی سیکلوستر آلکین آسید
کلمات کلیدی
کروماتوگرافی تبادل آنیون کریل، آلکالوئیدهای سینچونا، شیمی کلیک کنید مس کاتالیز، جداسازی انانتیوم، کروماتوگرافی مایع
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The synthesis and chromatographic evaluation of a series of new Cinchona derived chiral weak anion exchangers is presented. Huisgen Cu(I) mediated alkyne-azide cycloaddition, so-called click chemistry, was used as an immobilization strategy. In this way it was possible to immobilize about 90% of offered selector via 1,2,3-triazole linker, which displays a more efficient way of binding the selector to modified silica compared to common radical mediated thiol-ene addition. Problems associated with potential radical scavenging properties of chiral selectors thereby could be circumvented. The evaluation of the synthesized chiral stationary phases regarding chromatographic behavior was carried out using polar organic mode mobile phase composition and a set of representative chiral organic acids. Different loading densities revealed an optimum selector density of about 310 μmol/g chiral stationary phase with respect to resolution and selectivity. A decrease of performance was observed for higher loading, indicating mutual spatial influence of selector units leading to sterical hindrance. In addition, we observed that the effect of free azide groups on retention is negligible and the overall chromatographic behavior is comparable to other Cinchona derived chiral stationary phases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1337, 11 April 2014, Pages 85-94
نویسندگان
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