Characterization and multi-mode liquid chromatographic application of 4-propylaminomethyl benzoic acid bonded silica-A zwitterionic stationary phase

► A synthesis of 4-propylaminomethyl benzoic acid (PAMBA)-bonded silica is described. ► PAMBA-silica is a versatile multifunctional chromatographic stationary phase. ► PAMBA-silica operates in both anion and cation exchange chromatographic modes. ► PAMBA-silica operates in a hydrophilic interaction liquid chromatography mode.