On the chromatographic efficiency of analytical scale column format porous polymer monoliths: Interplay of morphology and nanoscale gel porosity

► Porous polymer monoliths always contain a distribution of subnanometer-sized pores. ► Nanometer-sized pore space changes with mobile phase solvent composition. ► Transport efficiency is ruled by modulated porous gel structure. ► Polymer feature size and interstitial pore size affects transport efficiency. ► Lower permeability, smaller phase ratio, finer globule structure improve performance.