Assessing the phenolic profile, antioxidant, antidiabetic and protective effects against oxidative damage in human erythrocytes of peaches from Fundão

In this work, the phenolic profile and biological potential of six peach cultivars from Fundão region (Portugal) were evaluated. The LC-DAD analysis revealed a total of 3 anthocyanins, and 14 non-colored phenolics. The antioxidant potential was evaluated against DPPH and NO radicals. Royal Lu proved to be the most active against DPPH (IC50 = 62.1 ± 1.5 μg/mL), and Sweet Dreams was the most active against NO radical (IC50 = 256.7 ± 60.4 μg/mL). Regarding the α-glucosidase inhibitory activity, Royal Magister and Royal Glory present the highest activity (IC50 = 11.7 ± 1.4 and 17.1 ± 1.7 μg/mL, respectively). Finally, the protective effect of Royal Lu to prevent oxidative damage in human erythrocytes induced by ROO was performed. Royal Lu proved to be quite efficient with promising results for hemolysis (IC50 = 110.0 ± 4.5 μg/mL) and hemoglobin oxidation inhibition (IC50 = 83.8 ± 6.5 μg/mL).