کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622208 | 1494523 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulatory impact of selected ellagitannins on the viability of human breast cancer cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modulatory impact of selected ellagitannins on the viability of human breast cancer cells Modulatory impact of selected ellagitannins on the viability of human breast cancer cells](/preview/png/7622208.png)
چکیده انگلیسی
The impact of agrimoniin, sanguiin H-6, rugosins D and A, tellimagrandin I, and pedunculagin on Adriamycin-resistant (MCF-7/Adr) and wild-type (MCF-7/wt) human breast cancer cell lines was evaluated with MTT assay. An inhibitory effect on MCF-7/wt cells viability grew stronger with the number of functional units: hexahydroxydiphenoyl (HHDP) group - releasable in the form of ellagic acid (EA), and HHDP derivatives (releasable in the form of EA derivatives). Thus agrimoniin (with five units) was the most active, pedunculagin and rugosin D (with two units each) exhibited medium impact, and rugosin A and tellimagrandin I (both with 1 unit) were the least active. Sanguiin H-6 was the only compound which inhibited MCF-7/Adr cells. It might be hypothesized that the characteristic for sanguiin H-6 structural sanguisorboyl unit contributed to the effect on MCF-7/Adr cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 122-128
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 122-128
نویسندگان
Izabela Berdowska, Bogdan ZieliÅski, Jolanta Saczko, MirosÅaw Sopel, Andrzej Gamian, Izabela Fecka,