کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622336 | 1494523 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ROS-modulating anticancer effects of gastrointestinally digested Ribes nigrum L. fruit extract in human colon cancer cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Reactive oxygen species (ROS) and antioxidants play a crucial role in dose-dependent promotion and suppression of colorectal tumourigenesis. In this study, ROS-modulating anticancer effects were analysed in colon cancer HT-29 cells exposed to the blackcurrant (BC) extract digested in an artificial gastrointestinal tract. The obtained results indicate that the colon-available fraction of gastrointestinal-digested BC extract dose-dependently inhibited the growth of colon cancer cells by inducing a G0/G1 phase cell cycle arrest and targeting cells to a caspase 3-mediated apoptosis pathway. The extract significantly suppressed cell invasion by down-regulation of matrix metalloproteinase MMP-2 and MMP-9 expression. The anticancer effect of the BC extract was related to the dose-dependent modulation of intracellular ROS accumulation. Given the bioavailability of BC polyphenols to the colon and their multi-directional anticancer activity, BC fruit may be proposed as a natural therapeutic agent and functional food ingredient to support prevention and treatment of colorectal cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 224-236
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 224-236
نویسندگان
Anna Olejnik, Mariusz Kaczmarek, Mariola Olkowicz, Katarzyna Kowalska, Wojciech Juzwa, RadosÅaw DembczyÅski,