کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623456 | 1494546 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyphenols rich Hibiscus rosa sinensis Linn. petals modulate diabetic stress signalling pathways in streptozotocin-induced experimental diabetic rats
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کلمات کلیدی
Hibiscus rosa sinensisp-Coumaric acid (PubChem CID: 637542) - p-Coumaric اسید (PubChem CID: 637542)Antioxidant enzymes - آنزیم های آنتی اکسیدانstreptozotocin - استرپتوزوتوسینEllagic Acid (PubChem CID: 5281855) - اسید الاجیک (PubChem CID: 5281855)Syringic acid (PubChem CID: 10742) - اسید سیرینژیک (PubChem CID: 10742)Cinnamic Acid (PubChem CID: 444539) - اسید سینامیک (PubChem CID: 444539)Ferulic acid (PubChem CID: 445858) - اسید فرولیک (PubChem CID: 445858)Caffeic acid (PubChem CID: 689043) - اسید کافئیک (PubChem CID: 689043)Chlorogenic acid (PubChem CID: 1794427) - اسید کلرژنیک (PubChem CID: 1794427)Diabetes mellitus - دیابت قندیMyricetin (PubChem CID: 5281672) - میریستین (PubChem CID: 5281672)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Polyphenols rich Hibiscus rosa sinensis Linn. petals modulate diabetic stress signalling pathways in streptozotocin-induced experimental diabetic rats Polyphenols rich Hibiscus rosa sinensis Linn. petals modulate diabetic stress signalling pathways in streptozotocin-induced experimental diabetic rats](/preview/png/7623456.png)
چکیده انگلیسی
Hibiscus rosa sinensis L. petals have an impressive range of medicinal uses and are edible with high nutritional value. In the present study, the anti-diabetic potential of Hibiscus was evaluated. HPLC-DAD and LCMS analyses of ethyl acetate fraction of Hibiscus (EHRS) revealed the presence of eight potent phytochemicals. Anti-diabetic effect was evaluated by the intra-gastric administration of EHRS at the dose of 25âmg/kg body weight in streptozotocin-induced experimental diabetic rats and compared with metformin. Streptozotocin-induced alterations of blood glucose, glycated haemoglobin, toxicity markers and antioxidant defence system were normalised by EHRS administration. EHRS significantly modulated the expressions of marker genes involved in diabetic stress signalling pathway, such as NF-κB, P38MAPK, AKT, PI3K and Nrf2. The histopathological studies of liver reinforce our findings. The overall effect was comparable with metformin. The study reveals the efficacy of Hibiscus as a potent source of phytochemicals in ameliorating diabetic complications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 31-42
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 31-42
نویسندگان
Sneha S. Pillai, S. Mini,