کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624277 | 1494547 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L.âcasei LBC80R and L.ârhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
flavin adenine dinucleotideDTDMAMCDNBIBDBCAGITDMHAOMGSTACFNADPazoxymethaneCACFAPHNPCCCCACCFUDT-diaphorase5-FUbicinchoninic acid protein1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزن3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromideBSA - BSAMTT - MTTLAB - آزمایشگاهbovine serum albumin - آلبومین سرم گاوProbiotic bacteria - باکتری های پروبیوتیکLactic acid bacteria - باکتریهای اسیدلاکتیکFAD - بدInflammatory bowel disease - بیماریهای التهابی رودهGastrointestinal tract - دستگاه گوارشDimethylhydrazine - دی متیل هیدرازینColorectal cancer - سرطان روده بزرگcolitis-associated cancer - سرطان مرتبط با کولیتFermented milk - شیر تخمیر شدهAnticancer - ضد سرطان5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلaberrant crypt foci - فوریه کریپت ناپایدارmethylazoxymethanol - متیلازوکمتانولnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphatefamilial adenomatous polyposis - پولیپوز آدنوماتوس خانوادگیCRC - کد افزونگی دورهای Aberrant crypt - کریپت غیرعادیcolony forming unit - کلنی واحد تشکیلQuinone reductase - کوئینون ردوکتازglutathione-S-transferase - گلوتاتیون S-ترانسفراز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L.âcasei LBC80R and L.ârhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L.âcasei LBC80R and L.ârhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine](/preview/png/7624277.png)
چکیده انگلیسی
The effect of fermented milk (FM) consisting of three probiotic strains (Lactobacillus acidophilus CL1285, L.âcasei LBC80R and L.ârhamnosus CLR2) on colon cancer prevention in rats treated with dimethylhydrazine (DMH) was investigated. The rats were divided into 7 groups of 8 animals. Rats were fed with a high fat low fibre diet; group 1 was a negative control, while groups 2 to 7 were injected with DMH (30âmg/kg s.c.) once a week for six weeks. Groups 3 to 7 were gavaged respectively with 2, 1.5, 1, 0.5 and 0.25âml of FM every day. After 12 weeks, the rats were sacrificed and the colon, caecum and liver were collected. Aberrant crypt foci (ACF) in the colon were determined using a microscope. Detoxifying enzymes like quinone reductase (QR) and glutathione-S-transferase (GST) and faecal enzymes such as β-glucosidase and β-glucuronidase were evaluated by spectrophotometry. The rats fed with the three highest doses significantly lowered aberrant crypt (AC) count, while those supplemented with 1.5 and 2âml FM lowered significantly ACF count compared to group 2 (pââ¤â0.05). Rats fed with the highest doses significantly induced GST activity, while only rats fed with 2âml reduced significantly β-glucuronidase activity compared to group 2 (pââ¤â0.05). These results indicate that the FM could have a potential role in colorectal cancer prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 816-827
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 816-827
نویسندگان
Kerlynn Desrouillères, Mathieu Millette, Khanh Dang Vu, Romain Touja, Monique Lacroix,