کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7625648 | 1494575 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection
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کلمات کلیدی
FAAELSDEGUcharged aerosol detector - آشکارساز آئروسل باردارEvaporative Light Scattering Detector - آشکارساز پراکندگی نور تبخیریAlcohol ethoxylates - اتوکسیلات الکلFatty acid - اسید چربFatty alcohol - الکل چربCharged aerosol detection - تشخیص aerosol شارژCAD - طراحی به کمک رایانه یا کَدFatty acid methyl ester - متیل استر اسید چربFAME یا fatty acid methyl esters - متیل استرهای اسید چربAverage molecular weight - میانگین وزن مولکولیpolyethylene glycol - پلی اتیلن گلیکولPolysorbates - پلی ساکاریدPEG - پلیاتیلن گلیکول
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection](/preview/png/7625648.png)
چکیده انگلیسی
Macrogol-based emulsifiers and their respective precursor substances, i.e. macrogols (PEG), fatty acids (FA), and fatty alcohols (FAA), are widely used excipients which are usually characterized by a series of tests described within the European Pharmacopoeia (Ph. Eur.). Examples are bulk parameters such as the hydroxyl value, the peroxide value, and the determination of fatty acids composition by gas chromatography. The choice of tests depends on the emulsifier considered and its possible precursors. Though all methods are well established, most of them are time consuming and, in some cases, prone to errors and exhibit a low reproducibility. Here, an alternative and supplemental method was developed, using a HPLC-system coupled to a charged aerosol detector (CAD). Seven PEG samples, five saturated as well as two nonsaturated FA samples, and two FAA samples were analyzed. Together with these precursors, 13 macrogol-based emulsifiers of 3 different groups, i.e. macrogol ethers with FAA, macrogol esters with FA, and polysorbates, were successfully analyzed for oligomeric distribution and free precursor molecules in one run.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 160, 25 October 2018, Pages 212-221
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 160, 25 October 2018, Pages 212-221
نویسندگان
Christiane Theiss, Ulrike Holzgrabe,