A PCA-based chemometrics-assisted ATR-FTIR approach for the classification of polymorphs of cimetidine: Application to physical mixtures and tablets

- ATR-FTIR spectroscopy and PCA combined for differentiation among polymorphs of CIM.
- Four CIM forms classified in physical mixtures, laboratory-made tablets and commercial samples.
- The procedure is not time-consuming and requires minimum sample pre-treatment.
- The method enables quick and unequivocal confirmation of the use of form A of CIM in tablets.
- The developed procedure is non-destructive and complies with green analytical chemistry principles.