Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine

- The formation of genuine ternary complexes was demonstrated by NMR studies, IR-spectroscopy, DSC, TG and DRX.
- A higher drug amorphization was found for the lyophilized ternary complexes than the binary ones.
- A significant 29-fold increase in solubility was obtained for SMR in the complex with MβCD and MEG in water.
- The ternary complex with HPβCD provided significant enhancement effects on the release of SMR.
- The ternary complexes with βCD and MβCD produced additional retention effects on the release of SMR.