Simultaneous determination of clevidipine and its primary metabolite in dog plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study

- A method was developed for simultaneous determination of clevidipine and its metabolite H152/81.
- The LLOQ was low and the run time was 5.5 min.
- Clevidipine was relevantly more stable in plasma than in whole blood.
- The method was successfully applied to a pharmacokinetic study in dog.