کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7630812 1494642 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of free fatty acids in pharmaceutical lipids by 1H NMR and comparison with the classical acid value
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of free fatty acids in pharmaceutical lipids by 1H NMR and comparison with the classical acid value
چکیده انگلیسی
Indices like acid value, peroxide value, and saponification value play an important role in quality control and identification of lipids. Requirements on these parameters are given by the monographs of the European pharmacopeia. 1H NMR spectroscopy provides a fast and simple alternative to these classical approaches. In the present work a new 1H NMR approach to determine the acid value is described. The method was validated using a statistical approach based on a variance components model. The performance under repeatability and in-house reproducibility conditions was assessed. We applied this 1H NMR assay to a wide range of different fatty oils. A total of 305 oil and fat samples were examined by both the classical and the NMR method. Except for hard fat, the data obtained by the two methods were in good agreement. The 1H NMR method was adapted to analyse waxes and oleyloleat. Furthermore, the effect of solvent and in the case of castor oil the effect of the oil matrix on line broadening and chemical shift of the carboxyl group signal are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 93, May 2014, Pages 43-50
نویسندگان
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