Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of 1-β-d-arabinofuranosyluracil in human plasma and application to therapeutic drug monitoring in patient with leukemia

- The concentration of ara-U in human plasma was determined and validated by HPLC-MS/MS for the first time.
- The method was simple and sensitive.
- The method was applied to support the clinical study and the therapeutic drug monitoring.