کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7645830 1495030 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Étude historique de la visualisation des protéines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Étude historique de la visualisation des protéines
چکیده انگلیسی
The history of the visualization of proteins is inseparable from that of structural biology that studies the structure and spatial organization of biological macromolecules. The ancients had initially imagined proteins as organic nitrogen nuclei surrounded by a mineral copula. The determination at the atomic scale of the 3D structure of proteins uses biophysical approach techniques developed in the first half of the twentieth century. Crystallography by X-ray diffraction provides an electron density map. Nuclear magnetic resonance spectroscopy defines a map inter-proton distances and angles of torsion of the backbone of the protein. Electron cryomicroscopy gives a direct image of the input molecule in its aqueous medium. These three families of techniques are evolving dramatically to grow in accuracy, resolution and spatial and temporal analysis. Today these methods converge with interactive databases and dynamic modeling bioinformatics tools towards defining models of «protein ligands» bounds, the discovery of pharmacological inhibitors, the prediction of macromolecular structure and an increased understanding of folding diseases abnormal proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Francophone des Laboratoires - Volume 2017, Issue 488, January 2017, Pages 59-69
نویسندگان
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