Biologie des Maladies Cholestatiques Chroniques de l' Adulte

Choleatasis is defined as a defect in bile acid transport from the fiver to the intestine. Biochemical tests of cholestasis reflect, on one hand, hepatoceflular or cholangioceflular cell damage induced by bile acids (liver enzymes) and, on the other hand, functional consequences of altered bile secretion (serum bilirubin and bile acids). Liver biopsy has a key role in the diagnosis of chronic cholestasis. Main chronic cholestatic diseases in adults are primary biliary cirrhosis and primary sclerosing cholangitis. Medical therapy is based on ursodeoxycholic acid.