Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives

► The combination of aIL and dual CDs enhances the enantioseparation of β-blockers. ► We propose a hypothesis of enantioseparation mechanism using [GTMA]Cl and HDTM-β-CD. ► With FESI the LOD of the three pairs of enantiomers are greatly improved.