کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7751569 1499182 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA interaction, cytotoxicity, apoptotic activity, cell cycle arrest, reactive oxygen species and mitochondrial membrane potential assay induced by ruthenium(II) polypyridyl complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
DNA interaction, cytotoxicity, apoptotic activity, cell cycle arrest, reactive oxygen species and mitochondrial membrane potential assay induced by ruthenium(II) polypyridyl complexes
چکیده انگلیسی
Ru-1 and Ru-2 were synthesized. The cytotoxicity of these complexes towards BEL-7402, HeLa, MCF-7 and MG-63 cells was evaluated by MTT method. The apoptosis was investigated by morphology and flow cytometry, cell cycle arrest was studied by flow cytometry. ROS and mitochondrial membrane potential were performed by fluorescence microscopy, and DNA-binding was investigated by electronic absorption titration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 405, 24 August 2013, Pages 228-234
نویسندگان
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