کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7753829 1499404 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1
چکیده انگلیسی
Cycloalkanes were hydroxylated by cytochrome P450Bm3 variants (CYP102A1) with decoy molecules up to 8000-fold more efficiently than the wild-type enzyme alone. Different perfluorocarboxylic acids (PFCs) optimised the product formation rate (PFR) of select variant/cycloalkane combinations but did not enhance a variant (A74G/F87V/L188Q; GVQ) containing mutations in the substrate binding pocket.192
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 183, June 2018, Pages 137-145
نویسندگان
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