In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone

(i) Ar1CCH (1.2 equiv), PdCl2(PPh3)2, CuI, K2CO3, 9:1 DMF:H2O (v/v), rt, 5 h; (ii) ArB(OH)2, PdCl2(PPh3)2, PCy3, K2CO3, 3:1 dioxane-water (v/v), 80 °C, 2 h; (iii) PdCl2, CH3CN, 80 °C, 3 h.68