کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7784584 | 1500577 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica
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کلمات کلیدی
HCIIIdoAGlcAFIIaFXaheparin cofactor IIAPTTLMWHGlcNAcTSPGAGantithrombin - آنتی ترومبینiduronic acid - اسید iduronicGlucuronic acid - اسید گلوکورونیکThrombin - ترومبین یا فاکتور II Snail - حلزونactivated partial thromboplastin time - زمان ترومبوپلاستین جزئی فعال شده استthrombin time - زمان ترومبینprothrombin time - زمان پروترومبینChemical structure - ساختار شیمیاییDermatan sulfate - سولفات درماتانAnticoagulant - ضد انعقاد، پادبندFactor Xa - فاکتور XaHeparin - هپارین low-molecular-weight heparin - هپارین کم وزن مولکولیMolecular weight - وزن مولکولیGlycosaminoglycan - گلیکوزآمینوگلیکان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Edible snails have been widely used as a health food and medicine in many countries. A unique glycosaminoglycan (AF-GAG) was purified from Achatina fulica. Its structure was analyzed and characterized by chemical and instrumental methods, such as Fourier transform infrared spectroscopy, analysis of monosaccharide composition, and 1D/2D nuclear magnetic resonance spectroscopy. Chemical composition analysis indicated that AF-GAG is composed of iduronic acid (IdoA) and N-acetyl-glucosamine (GlcNAc) and its average molecular weight is 118 kDa. Structural analysis clarified that the uronic acid unit in glycosaminoglycan (GAG) is the fully epimerized and the sequence of AF-GAG is â4)-α-GlcNAc (1 â 4)-α-IdoA2S (1â. Although its structure with a uniform repeating disaccharide is similar to those of heparin and heparan sulfate, this GAG is structurally highly regular and homogeneous. Anticoagulant activity assays indicated that AF-GAG exhibits no anticoagulant activities, but considering its structural characteristic, other bioactivities such as heparanase inhibition may be worthy of further study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 181, 1 February 2018, Pages 433-441
Journal: Carbohydrate Polymers - Volume 181, 1 February 2018, Pages 433-441
نویسندگان
Jie Liu, Lutan Zhou, Zhicheng He, Na Gao, Feineng Shang, Jianping Xu, Zi Li, Zengming Yang, Mingyi Wu, Jinhua Zhao,