کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7793014 | 1500657 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Telmisartan complex augments solubility, dissolution and drug delivery in prostate cancer cells
ترجمه فارسی عنوان
پیچیدگی تلسسارتان، حلالیت، انحلال و تحویل دارو در سلولهای سرطانی پروستات را افزایش می دهد
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Telmisartan (TEL) requires superior bioavailability in cancer cell compartments. To meet these challenges, we have synthesized a 2-HP-β-CD-TEL complex with stability constant (Kc) of 2.39 Ã 10â3 mM. The absence in the FTIR spectrum of 2-HP-β-CD-TEL complex of the characteristic peaks of TEL at 1699 cmâ1 (carboxylic acid) and 741 and 756 cmâ1 (1,2-disubstituted benzene ring vibrations), is indicative of the encapsulation of TEL in the 2-HP-β-CD cavity. DSC and PXRD also confirmed the synthesis and amorphous structure of complex. The interaction of TEL with 2-HP-β-CD was examined by NMR and 2D-ROESY which affirms the encapsulation of TEL in the 2-HP-β-CD cavity in at least two orientations with equal binding energies. The complex also exhibited its superiority in both in vitro release and cytotoxicity experiments on prostate cancer, PC-3 cells as compared to free drug. These data warrant an in depth in vivo to scale-up the technology for the management of prostate cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 101, 30 January 2014, Pages 614-622
Journal: Carbohydrate Polymers - Volume 101, 30 January 2014, Pages 614-622
نویسندگان
Manveet Kaur, Richa Kaur Bhatia, Raghuvir R.S. Pissurlenkar, Evans C. Coutinho, Upendra Kumar Jain, Om Prakash Katare, Ramesh Chandra, Jitender Madan,