کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7793014 1500657 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telmisartan complex augments solubility, dissolution and drug delivery in prostate cancer cells
ترجمه فارسی عنوان
پیچیدگی تلسسارتان، حلالیت، انحلال و تحویل دارو در سلولهای سرطانی پروستات را افزایش می دهد
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Telmisartan (TEL) requires superior bioavailability in cancer cell compartments. To meet these challenges, we have synthesized a 2-HP-β-CD-TEL complex with stability constant (Kc) of 2.39 × 10−3 mM. The absence in the FTIR spectrum of 2-HP-β-CD-TEL complex of the characteristic peaks of TEL at 1699 cm−1 (carboxylic acid) and 741 and 756 cm−1 (1,2-disubstituted benzene ring vibrations), is indicative of the encapsulation of TEL in the 2-HP-β-CD cavity. DSC and PXRD also confirmed the synthesis and amorphous structure of complex. The interaction of TEL with 2-HP-β-CD was examined by NMR and 2D-ROESY which affirms the encapsulation of TEL in the 2-HP-β-CD cavity in at least two orientations with equal binding energies. The complex also exhibited its superiority in both in vitro release and cytotoxicity experiments on prostate cancer, PC-3 cells as compared to free drug. These data warrant an in depth in vivo to scale-up the technology for the management of prostate cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 101, 30 January 2014, Pages 614-622
نویسندگان
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