کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7843261 | 1506521 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solubility, molecular interactions and mixing thermodynamic properties of piperine in various pure solvents at different temperatures
ترجمه فارسی عنوان
حلالیت، تعامل مولکولی و خواص ترمودینامیکی پیپریرین در حلال های مختلف خالص در دماهای مختلف
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
In this study, the solubility, molecular interactions and mixing thermodynamic properties of a poorly water soluble bioactive compound piperine in twelve different pure solvents namely “water, methanol, ethanol, isopropyl alcohol (IPA), ethylene glycol (EG), propylene glycol (PG), 1-butanol, 2-butanol, ethyl acetate (EA), dimethyl sulfoxide (DMSO), polyethylene glycol-400 (PEG-400) and 2-(2-ethoxyethoxy) ethanol [Transcutol®]” were evaluated. The solubility of piperine was determined at temperatures “T = 298.2 K to 318.2 K” and pressure “p = 0.1 MPa”. The experimental solubility values of piperine were determined using a static equilibrium method by high-performance liquid chromatography at 254 nm. The solubility data of piperine obtained in this study was regressed using “van't Hoff and Apelblat models” with root mean square deviation values of < 5.0%. The solubilities of piperine in mole fraction were obtained maximum in Transcutol (9.17 Ã 10â 2) followed by PEG-400 (7.88 Ã 10â 2), DMSO (3.59 Ã 10â 3), 2-butanol (2.25 Ã 10â 2), 1-butanol (2.20 Ã 10â 2), IPA (1.82 Ã 10â 2), EA (1.54 Ã 10â 2), PG (1.47 Ã 10â 2), ethanol (1.34 Ã 10â 2), methanol (7.91 Ã 10â 3), EG (6.70 Ã 10â 3) and water (1.52 Ã 10â 5) at “T = 318.2 K”. Based on the results of activity coefficient, the solute-solvent interaction was seen maximum in piperine-Transcutol and piperine-PEG-400 in comparison with other solute-solvent combination studied. Mixing thermodynamic properties of piperine were determined by activity coefficient model and results indicated spontaneous and entropy-driven dissolution of piperine in most of the pure solvents studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 250, January 2018, Pages 63-70
Journal: Journal of Molecular Liquids - Volume 250, January 2018, Pages 63-70
نویسندگان
Sultan Alshehri, Nazrul Haq, Faiyaz Shakeel,