Cytotoxicity and DNA double-strand breaks in human gingival fibroblasts exposed to eluates of dental composites

Significant DNA-DSBs induction can be found in HGFs exposed to the eluates of Esthet.X® HD and Venus®. The interactive effects among released (co)monomers and additives may influence the cytotoxicity and induction of DNA-DSBs, compared to exposure with single composite component.