Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

► Mitochondrial dysfunction is an early event in Alzheimer's disease. ► VDAC1 protein levels are elevated in AD brains and cortical tissues from APP transgenic mice. ► VDAC1 is interacted with Aβ and phospho tau and disrupts the transport of metabolites. ► VDAC1 + Aβ and Aβ + phospho tau complexes cause defects in OXPHOS in AD neurons.