Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition

► Dietary curcumin supplementation leads to stable levels of curcumin in mice plasma. ► Curcumin binds to plasma TTR and increases TTR resistance to dissociation. ► Curcumin decreases TTR deposition and associated biomarkers in tissues. ► Curcumin or derivatives can be used for TTR amyloidosis therapy.