PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi

► 15dPGJ2 modulates inflammatory mediators in the hearts of mice infected with T. cruzi. ► NOS2, MMPs, TNF-α and IL-6 decrease in the hearts of 15dPGJ2-treated mice. ► PPARγ-dependent and ‐independent (NF-κB) pathways are involved in 15dPGJ2 effect.