RNA interference targeting cytosolic NADP+-dependent isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo

▶ NADPH is an essential reducing equivalent for fat and cholesterol biosynthesis. ▶ IDPc has been proposed as a key enzyme for supplying cytosolic NADPH. ▶ Knockdown of IDPc by RNA interference inhibited adipogenesis and lipid biosynthesis.