Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFκB‐BCL10 loop

► Exposure to common food additive carrageenan initiates protracted inflammation. ► The presence of NF-κB binding site in the BCL10 promoter sets up inflammatory loop. ► Both RelA and RelB bind to the NF-κB binding site in the BCL10 promoter. ► In contrast to carrageenan, DSS exposure does not initiate prolonged inflammation.