Controlling a master switch of adipocyte development and insulin sensitivity: Covalent modifications of PPARγ

► PPARγ is important in fat cell development. ► PPARγ plays a role in glucose homeostasis and is an anti-diabetic drug target. ► The activity of PPARγ is largely effected by covalent modifications. ► The activity of PPARγ is highly regulated by phosphorylation, SUMOylation and ubiquitylation.